Highlights:

• Preserving Müller cells trophism is essential, as Müller cells are a major cell type in the retina to maintain retinal structure, metabolism, and homeostasis.

• Müller cells play a key role in retinal diseases and their dysfunction - discussed here as Müller cells pathology - drives degenerative processes.

• “Müllerotrophism” and “Mülleropathy” should be considered new major therapeutic targets for retinal diseases.